DNA Mismatch Repair (MMR)
To develop in silico models of deoxynucleotide metabolism that facilitates drug and radiation dose time course optimizations, in the treatment of mismatch repair defective (MMR-) malignancies.
The long-term goal is to build a model of ionizing radiation (IR) damage driven iododeoxyuridine (IdUrd) incorporation into the DNA of quiescent cells as a model of tumor stem cells. A model is being developed and validated via wet-lab experiments to maximize differences in IdUrd-DNA between MMR-/+ cells. These add to chemoradiation studies in anti-cancer drug development.
- Ken Loparo (Systems)
- Tim Kinsella (Radiation Oncology)
- Tomas Radivoyevitch (Epidemiology)
This project has been made possible by the NIH-NCI P-20 Planning grant and has been sponsored by the Case Systems Biology Initiative through the Provost Opportunity Fund.