DNA Mismatch Repair (MMR)
Project Objective
To develop in silico models of deoxynucleotide metabolism that facilitates drug and radiation dose time course optimizations, in the treatment of mismatch repair defective (MMR-) malignancies.
Project Description
The long-term goal is to build a model of ionizing radiation (IR) damage driven iododeoxyuridine (IdUrd) incorporation into the DNA of quiescent cells as a model of tumor stem cells. A model is being developed and validated via wet-lab experiments to maximize differences in IdUrd-DNA between MMR-/+ cells. These add to chemoradiation studies in anti-cancer drug development.
Project Team
- Ken Loparo (Systems)
- Tim Kinsella (Radiation Oncology)
- Tomas Radivoyevitch (Epidemiology)
This project has been made possible by the NIH-NCI P-20 Planning grant and has been sponsored by the Case Systems Biology Initiative through the Provost Opportunity Fund.
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